Why Isamune Plus with Zinc? Just in Time for Winter

Each spray of new Isamune Plus with Zinc delivers a range of immune-supporting compounds quickly.

One in five people in the United States loses a day or more of work or school during the winter season — the risk of which is increased when stress, poor diet and lack of sleep are in the picture. Worried about another year of feeling miserable?

New Isamune® Plus with Zinc is one way to help keep immune cells up for the task. Our new formulation combines zinc with bovine colostrum, Echinacea and Reishi mushrooms. Together, these ingredients work synergistically to guard against and help fight off “foreign invaders” in the body.

The human immune system is a remarkably complex network of cells, tissues and organs that act as the body’s first line of defense against infection and disease. As a whole, the immune system comprises the skin, thymus, spleen, bone marrow, white blood cells, complement system, cytokines and several hormones. Each individual component plays an integral part in protecting us against microbes, toxins and viruses. Many different cell types are involved in the immune system including B and T cells, macrophages, granulocytes and hematopoietic stem cells.

In particular, white blood cells (macrophages) can engulf invading bacteria or viruses, or they can secrete cytokines to regulate the intensity and duration of an immune response—all designed to protect us from illness. T cells have a special role in the attack on these “foreign invaders” or “antigens” by turning on the production of specific antibodies, those Y-shaped proteins that bind specifically to antigens present on the bacterial or viral surface. Next, complement proteins are activated to “complement” the action of antibodies. Together, they signal the targeting and destruction of these pathogens by digesting their cellular components.

To maintain the proper function and integrity of this immunological defense, the immune system’s complexity requires a healthy diet containing numerous essential vitamins and minerals that act in concert. Staying healthy can also use a little help from a few supplements in Isamune Plus with Zinc to keep the immune system primed to fight against foreign invaders on a daily basis.


Zinc is a mineral involved directly in host defense. Zinc acts on thymulin, a hormone that promotes T-cell function and differentiation. A compromised immune response and increased oxidative stress is observed in humans and other animals deficient in zinc (1-7). A mild zinc deficiency causes an imbalance in T-helper cells and interferes with activities of interleukins, which are signaling proteins that regulate the immune response (3). Isamune Plus with Zinc contains zinc in the form of zinc gluconate, shown to help maintain reserves to guard against a compromised immune system (2).


Bovine colostrum is  the first milk produced by a cow after giving birth and has a distinct composition from the regular milk produced afterwards. Colostrum provides the mother an immediate ability to transfer immune-protecting substances to the newborn.

Colostrum contains several “immune factors” including: immunoglobulins, growth factors, cytokines, proline-rich polypeptides and lactoferrin (8-17). Immunoglobulins are a class of antibodies passed from the mother to provide her calf with the building blocks for a healthy immune system. Growth factors and cytokines support tissue rejuvenation (17). Proline-rich polypeptides (PRPs) help modulate the immune response by regulating cytokine synthesis (16, 17). Lactoferrin is an iron-containing protein that functions in iron homeostasis. Compounds in colostrum may also inhibit oxidative stress signaling pathways (13, 17).

The importance of human colostrum for the newborn’s immune system is well recognized and the components of bovine colostrum are relatively similar to those in humans. Studies suggest that supplementation with colostrum may strengthen the immune system in humans (8-10). Previous research found a statistically significant increase in levels of immunoglobulins in distance runners after 12 weeks of supplementation (10).

Isamune Plus with Zinc provides each of the important components in colostrum: immunoglobulins, PRPs and lactoferrin.


Echinacea (Echinacea purpurea) is a flowering plant from the daisy family, Asteraceae, and is endemic to North America. The perennial plant’s roots and leaves are traditionally used by Native Americans for its medicinal qualities. In recent randomized controlled trials, scientists found that a beneficial effect on the immune system was attributable to echinacea (21-23).

Reishi Mushroom

Reishi Mushroom (Ganoderma lucidum) is a woody mushroom highly regarded in traditional medicine and long consumed for its immune-modulating and overall health benefits. It’s unique in being consumed for it’s medicinal, rather than it’s nutritional, value (20-27).

In Japan, reishi mushroom is consumed either as a tea or powder and reputed to increase youthful vigor and vitality. One study showed significant beneficial changes in immune cells when given the mushroom extract for 12 weeks (24). Similarly, another study found that reishi mushroom stimulated immune system regulation (27). These results and others provide supporting evidence for the immunomodulatory effect of reishi mushroom.

Why a Spray Formula?

New Isamune Plus with Zinc

New Island Breeze flavor

Unlike pills or lozenges, Isamune Plus with Zinc is scientifically advanced to deliver immune-building compounds in a convenient spray (now optimized) to instantly go to work on guarding the body against foreign invaders.

The spray allows for easy-and-quick administration and immediate delivery of immune-supporting ingredients. Isamune Plus with Zinc is recommended in the amount of five sprays per day to maintain a functioning and healthy immune system.

With its new Island Breeze flavor (containing hints of pomegranate and spearmint), each spray of Isamune Plus with Zinc is also enjoyable for the whole family.


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